Destructurling works in many places, as well as in the param list of an fn:

(defn my-func [[_ a b]]
  (+ a b))

(my-func [1 2 3]) ;= 5
(my-func (range 5)) ;= 3

Destructuring also works for the & rest construct in the param list:

(defn my-func2 [& [_ a b]]
  (+ a b))

(my-func2 1 2 3) ;= 5
(apply my-func2 (range 5)) ;= 3